A deficiency of an important enzyme in the body causes kidney disease

A new hope for prevention and treatment of an increasingly widespread disease classified by the World Health Organization as the tenth cause of death for millions worldwide

Published in:
Last Updated:

According to New Atlas, a team of University of Pennsylvania scientists has identified a role for an enzyme called nicotinamide adenine dinucleotide (NAD+) in kidney disease. New Atlas Cited from Nature Metabolism.

According to the World Health Organization (WHO), kidney disease has risen from the 13th to the 10th leading cause of death. In 2019, 1.3 million people died from kidney disease. But if kidney disease is detected and treated early, it is often possible to slow or stop kidney failure.

Revealing

Metabolic balance

NAD+ coenzyme Nicotinamide adenine dinucleotide is a coenzyme found in every cell that regulates various metabolic pathways, as well as being involved in DNA repair and immune cell function. It is essential to maintain metabolic balance through its effect on the mitochondria, the energy generators in the cell, and without adequate amounts of enzymes, the body’s cells cannot generate the energy they need to perform their metabolic functions.

Tubular cells in the kidneys need a lot of energy produced by mitochondria to perform their function, reabsorb essential nutrients and excrete waste and toxins. When the mitochondria in these cells are damaged, an inflammatory response is triggered that leads to kidney disease, which causes the body to build up fluid, electrolytes, and waste products.

See also  How can you improve your mental health? .. The most important reason is to be satisfied

Human models for the first time

In the new study, researchers used metabolomics, a study of small molecules found in blood and urine, to map metabolic changes in human kidneys. It gives the amount of metabolites, which are very small molecules produced during metabolism; Insights into a person’s health. This is the first time that human models have been used in metabolomics studies.

Kidneys

The underlying disease mechanism

The researchers tested kidney samples from a healthy control group against samples from patients with diabetic kidney disease or kidney disease caused by high blood pressure. It turns out that NAD+ levels are significantly lower in diseased kidneys. To investigate the disease mechanism underlying these differences, they performed RNA-sequencing of the samples.

Prevents kidney damage

The researchers sought to determine the relationship between NAD+ levels and mitochondrial gene expression, and concluded that low NAD+ levels are a key feature of human kidney disease. Furthermore, when laboratory mice were given over-the-counter supplements of the NAD+ precursor nicotinamide riboside or nicotinamide mononucleotide (NMN) to increase NAD+ levels, tubular cell mitochondria were protected from damage and prevented the development of kidney disease.

Developing treatment regimens

The principal investigator of the study, Katalin Sostak, believes that “this research will lead to improved care in the future, so that if patients have metabolic changes, they can be treated before kidney disorders become apparent.”

The researchers hope that their study will lead to further studies of the role of metabolites in kidney disease and the development of new approaches to prevention and treatment.

See also  There is a scientific reason.. Why did the New York sky turn orange in the fire in Canada?

“Identifying NAD+-sensitive downstream mechanisms is critical to understanding conditions that may benefit from NAD+ supplementation,” said study co-author Joseph Bauer.

Read more

  • Nadia Barnett

    "Award-winning beer geek. Extreme coffeeaholic. Introvert. Avid travel specialist. Hipster-friendly communicator."

    Related Posts

    • science
    • January 11, 2024
    • 503 views
    A “supermaterial” of carbon… science when the Chinese kill two birds with one stone

    Just type “carbon dioxide recycling” into a search engine for scientific research, “Google Scholar,” and you'll be greeted with dozens of success stories in which the heroes are researchers who…

    • science
    • January 10, 2024
    • 411 views
    The Future of Peace and Development in Yemen in Light of the Trap of Psychological Disorders (1) | Dr. Muhammad al-Maithami

    A husband sticks a cigarette in his wife's eyes. Inadequate shelter. She then commits suicide, and by doing so will provide them with comfort, peace and tranquility at home. The…

    Leave a Reply

    Your email address will not be published. Required fields are marked *

    You Missed

    How to Choose the Right Mattress: Find the Best Fit for You

    How to Choose the Right Mattress: Find the Best Fit for You

    Emils Kerimovs on Wealthtech Revolution: Investing in the Middle East and Africa

    Emils Kerimovs on Wealthtech Revolution: Investing in the Middle East and Africa

    Forex Brokers Review: Is ITBFX A Safe Broker?

    Forex Brokers Review: Is ITBFX A Safe Broker?

    Best Kitchen Renovation Ideas to Upgrade Your Space

    Best Kitchen Renovation Ideas to Upgrade Your Space

    Where to Get a Professional Massage in Dubai

    Where to Get a Professional Massage in Dubai

    Dog Spay Surgery 101: Benefits, Risks, Cost, and Aftercare

    Dog Spay Surgery 101: Benefits, Risks, Cost, and Aftercare